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KMID : 0613820190290050614
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Journal of Life Science
2019 Volume.29 No. 5 p.614 ~ p.620
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Evaluation of the Effect of Oriental Medicinal Herbs with Growth Factors on Bone Development using the SD Strain Rat Model in the Growth Period
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Sim Jae-Won
Ahn Hee-Young
Sim So-Yeon
Kim Hee-Young
Cho Yong-Ju
Cho Young-Su
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Abstract
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The purpose of this study was to examine the growth plate, femoral bone length, bone mineral density, and blood composition in various experimental animals fed with oriental medicinal herbs containing growth factors. First, the lengths of the bone growth plates of the positive control (PC) group (fed with Astragalus membranaceus) and the Gh-199 and Sh-188 groups were increased when compared to group N. The Gh-199 group showed a greater increase in bone growth when compared with the PC group. In terms of the femoral bone length and bone mineral density, the effect of both Gh-199 and Sh-188 powders were as good as those of the PC group, and the Gh-199 powder showed a positive effect. Conversely, in the PC group, unlike the Gh-199 and Sh-188 groups, the aspartate aminotransferase(AST) and alanine aminotransferase(ALT) activities in the blood were increased, indicating that A. membranaceus is toxic to the body. Both the PC and Sh-188 groups also showed higher insulin-like growth factor-1(IGF-1) activity when compared with the Gh-199 group. Overall, the bone growth plate, femoral bone length, and bone mineral density measurements, and the blood analysis showed positive results in the group treated with Gh-199, and no specific toxicity of the herbal medicine in the body was evident.
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KEYWORD
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Femoral bone length, growth, growth plate, height, herbal medicinal
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